**Introducing COOLIEF* Cooled RF Probes Advanced**

90-Degree Angle.^† Reduced Risk of C-arm Interference.^†

The COOLIEF* Cooled RF Probes Advanced have a 90-degree handle making them less top heavy when compared to our COOLIEF* Cooled RF Probes^†. In addition, the COOLIEF* Advanced Kit packaging has reduced size and volume when compared to the predicate packaging, allowing it to be more efficient with shelf space and generate less waste.^† Benefits of the next-generation COOLIEF* Cooled RF Advanced:

90-degree handle is shorter than the COOLIEF* Cooled RF Probe handle, thus reducing the risk of interference with a C-Arm^†

Lesions created by the COOLIEF* Cooled RF Probe Advanced are substantially equivalent in size and shape to the lesions created by the COOLIEF* Cooled RF Probe devices^†

Feature a flouromarker to aid in the visualization and confirmation of the probe tip^†

Compatible with sterile water, saline or Ringer’s lactate IV bags^†

COOLIEF* Probe Advanced and CRA-TBK Tubing Kits are backwards and forwards compatible with all existing Avanos COOLIEF* compatible products including all introducers, generators, and pumps.^†

Target Chronic Pain Modalities

**Why Use COOLIEF* Coolied Radiofrequency?**

COOLIEF* is a minimally invasive effective treatment for a wide range of chronic pain patients, treating chronic knee, cervical, lumbar back, sacroiliac joint, thoracic facet, discogenic back, and hip joint pain.^† With COOLIEF Cooled RFA, water-cooled electrodes enable more RFA energy to be delivered than conventional RFA, creating lesions that distally project more than 45% beyond the probe’s tip, resulting in a spherically-shaped lesion that can reach up to 12mm in width (in bench testing).^†

Extended durability – clinical trials have demonstrated up to 24 months of pain relief¹

Clinically proven by level 1 evidence^†

Delivers up to 3.7 times more energy than standard RF^†

WATER COOLED PROBES

Product Code (SKU)	Probe Gauge	Probe Length (mm)
CRPA-17-100	17	100
CRPA-17-150	17	150
CRPA-17-50	17	50
CRPA-17-75	17	75
TDP-17-150	17	150

Innovate Every Day

For more than 20 years, Avanos has been dedicated to providing innovative, non-opioid pain relief solutions that allow patients to get back to what matters.

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DISCLAIMERS:

† Claims Data on File at Avanos

1) Bellini M et al. (2015) Cooled radiofrequency system relieves chronic knee osteoarthritis pain: the first case-series. Anaesthesiology Intensive Therapy vol. 47: 30-33.; Burnham T et al. (2020) The Effectiveness of Cervical Medial Branch Radiofrequency Ablation for Chronic Facet Joint Syndrome in Patients Selected by a Practical Medial Branch Block Paradigm. Pain Management (0): 1-6.; Chen A.F et al. (2020) Cooled radiofrequency ablation provides extended clinical utility in the management of knee osteoarthritis: 12-month results from a prospective, multi-center, randomized, cross-over trial comparing cooled radiofrequency ablation to a single hyaluronic acid injection. (21): 363.; Davis T et al. (2019) Twelve-month analgesia and rescue, by cooled radiofrequency ablation treatment of osteoarthritic knee pain: results from a prospective, multicenter, randomized, cross-over trial. Reg Anesth Pain Med (0): 1-8.; Ho K et al. (2013) Cooled radiofrequency denervation for treatment of sacroiliac joint pain: two-year results from 20 cases. Journal of Pain Research (6):505-511.; Hunter H et al. (2020) Cooled Radiofrequency Ablation Treatment of the Genicular Nerves in the Treatment of Osteoarthritic Knee Pain: 18- and 24-Month Results. Pain Practice (20): 238-246.; Kapural L et al. (2019) Long-Term Retrospective Assessment of Clinical Efficacy of Radiofrequency Ablation of the Knee Using a Cooled Radiofrequency System. Pain Physician (22): 489-494.; Kapural L et al. (2021) Cooled Radiofrequency Ablation of the Articular Sensory Branches of the Obturator and Femoral Nerves using Fluoroscopy and Ultrasound Guidance: A Large Retrospective Study. Pain Physician (24): 611-617.; Lyman J et al. (2022) Cooled radiofrequency ablation of genicular nerves provides 24-Month durability in the management of osteoarthritic knee pain: Outcomes from a prospective, multicenter, randomized trial. Pain Practice (00):1-11.

Introducing COOLIEF* Cooled RF Probes Advanced

90-Degree Angle.† Reduced Risk of C-arm Interference.†